实验室已在多项研究中取得显著成果，包括首次揭示非典型NF-κB通路的激活机制及其在抗肿瘤和自身免疫中的重要作用，探索泛素化调控T细胞反应的新机制，及识别调节肿瘤生长和免疫抑制的关键蛋白激酶TBK1。我们致力于将基础研究与临床应用相结合，为免疫治疗的发展贡献创新思路。
使用信号转导，CRISPR基因筛选，单细胞RNA测序，和基因敲除小鼠等多种方法研究T细胞激活，分化，效应功能和耗竭的分子机理，从而鉴定关键性T细胞调节因子
孙教授的研究成果发表于Nature、Science、Nature Medicine、Nature Immunology等国际顶尖期刊，累计发表论文200余篇，并获得多项国际权威学术奖项。他的工作曾获美国国立卫生研究院（NIH）、德克萨斯州癌症预防与研究所（CPRIT）等机构的持续资助。
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature, 2013, 494: 371-374. DOI: 10.1038/nature11831
Xiao Y, Jin J, Chang M, Chang JH, Hu H, Zhou X, Brittain GC, Stansberg C, Torkildsen Ø, Wang X, Brink R, Cheng X, Sun SC. Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation. Nature Medicine, 2013, 19: 595-602. DOI: 10.1038/nm.3111
Jin J, Hu H, Li HS, Yu J, Xiao Y, Brittain GC, Zou Q, Cheng X, Mallette FA, Watowich SS, Sun SC. Noncanonical NF-κB pathway controls the production of type I interferons in antiviral innate immunity. Immunity, 2014, 40: 342-354. DOI: 10.1016/j.immuni.2014.02.006
Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity, 2014, 40: 692-705. DOI: 10.1016/j.immuni.2014.04.007
Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nature Immunology, 2014, 15: 562-570. DOI: 10.1038/ni.2885
Zhu L, Zhou X, Kim J, Gu M, Xie X, Li Y, Ko CJ, Gao T, Cheng X, Sun SC. Dapl1 controls NFATc2 activation to regulate CD8+ T cell exhaustion and responses in chronic infection and cancer. Nature Cell Biology, 2022, 24: 1165-1176. DOI: 10.1038/s41556-022-00942-8
Gu M*, Zhou X*, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC. NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity. Nature Immunology, 2021, 22: 193-204. DOI: 10.1038/s41590-020-00829-6
Zhu L, Li Y, Xie X, Zhou X, Gu M, Jie Z, Ko CJ, Gao T, Hernandez BE, Cheng X, Sun SC. TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis. Nature Cell Biology, 2019, 21: 1604-1614. DOI: 10.1038/s41467-018-05097-5
Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. The deubiquitinase Otub1 controls the activation of CD8(+) T cells and NK cells by regulating IL-15-mediated priming. Nature Immunology, 2019, 20: 879-889. DOI: 10.1038/s41590-019-0405-2
Jie Z, Yang JY, Gu M, Wang H, Xie X, Li Y, Liu T, Zhu L, Shi J, Zhang L, Zhou X, Joo D, Brightbill HD, Cong Y, Lin D, Cheng X, and Sun SC. NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis. Nature Immunology, 2018, 19: 1224-1235. DOI: 10.1038/s41590-018-0206-z.
Jin J, Xie X, Xiao Y, Hu H, Zou Q, Cheng X, Sun SC. Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nature Immunology, 2016, 17: 259-268. DOI: 10.1038/ni.3347
本招生长期有效，至招聘到合适人选为止。
本招聘长期有效，至招聘到合适人选为止。
sunxiao@cimrbj.ac.cn