谭旭实验室致力于运用先进的高通量筛选方法进行抗病毒药物疫苗开发研究，同时运用功能基因组学大规模遗传筛选的方法以及全蛋白组质谱的手段来系统的研究人类抗病毒免疫的机制。
实验室对基于RNA的药物和疫苗开发，蛋白降解类小分子药物（PROTAC和分子胶水）开发也非常有兴趣。
实验室前期研究针对新冠病毒，艾滋病毒，乙肝病毒和寨卡病毒等发现多种新型抗病毒药物靶点和候选药物分子。
运用人类全基因组过表达文库 (ORFeome)筛选重要病毒的宿主因子，从中发现新型抗病毒药物靶点。
运用高通量药物筛选方法在细胞模型上筛选抗病毒药物小分子并进行其作用机制研究。
运用新型细胞免疫表位发现方法（TScan）进行抗病毒和抗肿瘤的细胞免疫表位的系统发现及后续mRNA疫苗的开发。
Mei M*, Impagnatiello MA*, Jiao J, Reiser U, Tontsch-Grunt U, Zhang J, Nicklin P, Yu B, Wang Y, He Y#, Tan X#. An orally available monovalent SMAC mimetic compound as a broad-spectrum antiviral. Protein & Cell, 2024, DOI: 10.1093/procel/pwad033.
Li S*, Qian N*, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X. Gain-of-function genetic screening identifies antiviral function of TMEM120A via activating STING signaling. Nature Communications, 2022, 13:105. DOl: 10.1038/s41467-021-27670-1.
Anderson DE*, Cui J*, Ye Q*, Huang B*, Tan Y, Jiang C, Zu W, Gong J, Liu W, Kim SY, Yan BG, Sigmundsson K, Lim XF, Ye F, Niu P, Irving AT, Zhang H, Tang Y, Zhou X, Wang Y, Tan W, Wang LF#, Tan X#. Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy. Proc Natl Acad Sci USA, 2021, 118: e2104759118. DOl: 10.1073/pnas.2104759118.
Zhang H*, Deng S*, Ren L, Zheng P, Hu X, Jin T#, Tan X#. Profiling CD8 + T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants. Cell Reports, 2021, 36:109708. DOl: 10.1016/j.celrep.2021.109708.
Liu Y*, Song Y*, Zhang S, Diao M, Huang S, Li S, Tan X. PSGL-1 inhibits HIV-1 infection by restricting actin dynamics and sequestering HIV envelope proteins. Cell Discovery, 2020, 6:53. DOI:.1038/s41421-020-0184-9.
Liu Y*, Fu Y*, Wang Q, Li M, Zhou Z, Dabbagh D, Fu C, Zhang H, Li S, Zhang T, Gong J, Kong X, Zhai W, Su J, Sun J, Zhang Y, Yu XF, Shao Z, Zhou F#, Wu Y#, Tan X#. Proteomic profiling of HIV-1 infection of human CD4+ T cells identifies PSGL-1 as an HIV restriction factor. Nature Microbiology, 2019, 4(5):813. DOl: 10.1038/s41564-019-0372-2.
Li P*, Wei Y*, Mei M*, Tang L*, Sun L, Huang W, Zhou J, Zou C, Zhang S, Qin CF, Jiang T, Dai J, Tan X#, Zhang QC#. Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity. Cell Host &Microbe, 2018, 24(6):875. DOl: 10.1016/j.chom.2018.10.011.
Jiang C*, Mei M*, Li B*, Zhu X*, Zu W, Tian Y, Wang Q, Guo Y, Dong Y#, Tan X#.A non-viral CRISPR/Cas9 delivery system for therapeutically targeting HBV DNA and PCSK9 in vivo. Cell Research, 2017, 27(3):440. DOl: 10.1038/cr.2017.16.
Lin Z*, Li S*, Feng C*, Yang S, Wang H, Ma D, Zhang J, Gou M, Bu D, Zhang T, Kong X, Wang X, Sarig O, Ren Y, Dai L, Liu H, Zhang J, Li F, Hu Y, Padalon-Brauch G, Vodo D, Zhou F, Chen T, Deng H, Sprecher E, Yang Y#, Tan X#. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nature Genetics, 2016, 48(12): 1508. DOl: 10.1038/ng.3701.
Tan X, Calderon-Villalobos LIA, Sharon M, Zheng C, Robinson CV, Estelle M & Zheng N, Mechanism of Auxin Perception by the TIR1 ubiquitin ligase. (2007) Nature 446(7136): 640(Cover Article)
本招生长期有效，至招聘到合适人选为止。
本招生长期有效，至招聘到合适人选为止。
xtan@cimrbj.ac.cn